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Animal experiments All procedures performed in rats were approved by the Institutional Animal Care and Use Committee at the Seattle Childrens Research Institute (IACUC00064) and were in accordance with the National Institutes of Health (NIH) Guide for Care and Use of Laboratory Animals

AcAc is converted in a reversible reaction catalyzed by D--hydroxybutyrate dehydrogenase (BDH1), leading to the formation of BHB, or undergoes non-enzymatic decarboxylation with the formation of acetone (Figure 2) (104, 105)

Sovateltide is in a Phase 2 randomized, double-blind placebo-controlled trial (NCT04052737)

This makes it the first GLP-1 therapy approved for MASH and positions it as a potential treatment to not only halt disease progression but also reverse liver damage